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Thiamine hydrochloride (Vitamin B1) 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。
Thiamine hydrochloride (Vitamin B1) 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
20 mg | ¥ 110 | 现货 | |
100 mg | ¥ 400 | 现货 |
产品描述 | Thiamine hydrochloride (Vitamin B1) is the hydrochloride salt form of thiamine, a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Upon hydrolysis, Thiamine hydrochloride (Vitamin B1) is phosphorylated by thiamine diphosphokinase to form active thiamine pyrophosphate (TPP), also known as cocarboxylase. TPP is a coenzyme for many enzymatic activities involving fatty acid, amino acid and carbohydrate metabolism. |
体外活性 | Thiamine hydrochloride(50 mM)除了其营养价值外,还能在水稻、烟草、黄瓜和拟南芥(Arabidopsis thaliana)中诱导系统获得性抗性(SAR)。经Thiamine hydrochloride处理的水稻、拟南芥和蔬菜作物表现出对真菌、细菌和病毒感染的抗性。Thiamine hydrochloride处理能诱导水稻等植物中病原相关(PR)基因的短暂表达。此外,Thiamine hydrochloride处理加强并加速了PR基因表达和蛋白激酶C活性的上调。[1] 维生素B1(10 μM)可预防乙醛抑制成年大鼠心室肌细胞短缩的作用。维生素B1(10 μM)有效减轻乙醛诱导的成年大鼠心室肌细胞±dL/dt下降。维生素B1(10 μM)可防止乙醛缩短成年大鼠心室肌细胞至峰短缩时间。维生素B1(10 μM)能预防乙醛诱导的成年大鼠心室肌细胞蛋白羰基形成和caspase-3活化水平升高。[2] Thiamine hydrochloride的摄取是能量和温度依赖的、pH敏感的、在ARPE-19细胞中Na+独立的,并在纳摩尔级(Km 为 30 nM)及微摩尔级浓度范围内饱和。ARPE-19细胞中的Thiamine hydrochloride摄取通过细胞外底物水平适应性调节、涉及hTHTR-1和hTHTR-2转录介导的机制和受到细胞内Ca2+-钙调蛋白介导的途径调控实现。[3] 对于Thiamine hydrochloride反应性巨细胞性贫血(TRMA)成纤维细胞,10 nM至30 nMThiamine hydrochloride可以拯救其免于死亡。正常成纤维细胞表现出高亲和性的Thiamine hydrochloride饱和摄取(Km 400 nM-550 nM;Vmax 11 pmol/min/1×10^6细胞),而TRMA成纤维细胞则缺乏可检测的高亲和性摄取。在30 nMThiamine hydrochloride下,TRMA成纤维细胞的Thiamine hydrochloride摄取速率是野生型的十分之一,这解释了TRMA成纤维细胞增加的凋亡。[4] |
体内活性 | Thiamine hydrochloride缺乏导致大鼠脑损伤(内部或周围的肿胀神经突起中)和小鼠中累积β-淀粉样前体蛋白导致免疫活性受损。[5] |
别名 | 盐酸硫胺素, 盐酸硫胺(维生素B1), Vitamin B1 hydrochloride, Vitamin B1, Thiamine HCl, Thiamine chloride hydrochloride |
分子量 | 337.27 |
分子式 | C12H18Cl2N4OS |
CAS No. | 67-03-8 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
溶解度信息 | H2O: 100 mg/mL (296.49 mM), Sonication is recommended. DMSO: 3.37 mg/mL (10.01 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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